May 01, 2020 drug metabolism pptpowerpoint presentation, medical notes edurev is made by best teachers of. Cyp1 drug metabolism 3 subfamilies, 3 genes, 1 pseudogene cyp2 drug and steroid metabolism subfamilies, 16 genes, 16 pseudogenes cyp3 drug metabolism. Guideline on the investigation of drug interactions. Introduction biotransformation is defined as the conversion from one chemical form to another synonym metabolism detoxification process these chemical changes takes place within our body in presence of some enzymes e. Drug metabolism oxidation humans have 18 families of cytochrome p450 genes and 43 subfamilies. Phase i metabolism involves small structural alterations to the drug molecule. Each student will independently develop a powerpoint presentation based on the student paper, and deliver the presentation in one of the final sessions of the semester. Oct 26, 2014 a drug may inhibit one isoenzyme while being itself a substrate of another isoenzyme e. Lipids are a distinct group of compounds, including oils, waxes, steroids, fats and similar compounds that are very much connected by their physical property rather than their chemical property. Since the liver is a major site of drug metabolism, this firstpass effect may reduce the amount of drug reaching the target tissue. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. Therefore, the effect of drugs on the rate of metabolism. Path of a drug after administration by any route, a drug will reach the blood stream as.
Medication use may result in undesired or adverse side effects. The potential for pharmacokinetic interactions between new medicinal products and already marketed drugs should be evaluated. Drug metabolism can be divided into phase i and phase ii metabolism. Drugdrug interaction an overview sciencedirect topics. They focus on the biochemical pathways that we find in humans, and they also take into account some physiological and clinical aspects. Ppt pharmacokinetics powerpoint presentation free to. For example, the rate of metabolism determines the duration and intensity of a drugs. Metabolism and energy powerpoint presentation teaching. Protein metabolism the body synthesizes 100,000 to 140,000 proteins each with different form, function, and structure all proteins are built from the 20 amino acids cellular proteins are recycled in cytosol peptide bonds are broken free amino acids are used in new proteins. Chapters 2 and 3 deal with the chemistry of drug biotransformation. Alcohol and other drug use percentage of high school students who ever drank alcohol, by type of grades earned mostly as, bs, cs or dsfs, 2009 had at least one drink of alcohol on at least 1 day during their life. Part 1 of the article covers the basics of drug metabolism. Familiar with invivo drug metabolism studies, pharmacokinetics and use of radi oisotopes.
The chemical modification of drugs with the overall goal of getting rid of the drug enzymes are typically involved in metabolism 3. To understand why certain drugs are contraindicated with other drugs. Two drugs are coadministered in the following situations. Jan 22, 2014 contents of the powerpoint on bioavailability and firstpass metabolism include. In part ii we will discuss the kinetics of drug metabolism and the relationship of kinetic data to the pharmacokinetics of a drug. A free powerpoint ppt presentation displayed as a flash slide show on id. Set 1 powerpoint links collected from the website of. It is a specific term used for chemical transformation of xenobiotics in the bodyliving organism. Role of metabolism in drug discovery 36 in drug development it is important to have an information on the enzymes responsible for the metabolism of the candidate drug invitro studies can give information about metabolite stability metabolite profile metabolite identification cyp inductioninhibition drug drug. For fine tune of biological activity in order to minimize toxicity modify the activity alter metabolism maximize bioavailability 7 powerpoint presentation. Percentage of high school students who ever drank alcohol, by type of grades earned mostly as, bs, cs or dsfs, 2009 had at least one drink of alcohol on at least 1 day during their life. Dec 10, 2016 metabolism and energy powerpoint presentation this is a 31 slide powerpoint presentation covering the following topics.
Pharmaceutic, pharmacokinetics, absorption, pharmacodynamics, side effects or adverse reactions, principles of drug administration the five rights, drug approval process, drug names, pharmacokinetic interaction, pharmacodynamic interactions, anticonvulsants, antipsychotics, antidepressant agent, antibacterial, drugs for. The primary purpose is to decrease lipophilicity and enhance renal excretion of the molecule. Translational research institute for metabolism and diabetes stephen gough, md, frcp uk. Energy definition types of energy kinetic and potential energy chemical energy gibbs free energy enthalpy and entropy free energy calculation endergonic and exergonic reactions metabolism anabolic and catabolic pathways anphibolic pathways it is designed for 11th12th year. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. Excretion renal vsnonrenal half life time for the blood concentration to decrease by half. Chapters 8 and 11 pharmacokinetics and pharmacodynamics pharmacodynamics is the study of how drugs interact with a molecular target, i. Files are presented courtesy of the respective instructors, used with permission.
Alcohol and other drug use centers for disease control. Ppt drug metabolism powerpoint presentation free to download id. Interaction of a drug with food that results in an adverse patient reaction. Enzyme induction free download as powerpoint presentation. Addiction affects all strata of society costs of addiction are high including death, lost productivity, costs to society and families prevalence of binge.
This helps you give your presentation on cholesterol metabolism in a conference, a school lecture, a business proposal, in a webinar and business and professional representa. Phase i and phase ii reactions of drug authorstream. Presentation topics rnai therapeutics mechanism of rnai introduction to sirnagalnac conjugates pharmacokinetic behavior and adme properties of sirnagalnac conjugates absorption and pk profile plasma and liver kinetics distribution in tissues and elimination metabolism. Such conditions harm the wellbeing and development of children in the home and may set the stage for drug abuse in the next generation. Pharmaceutic, pharmacokinetics, absorption, pharmacodynamics, side effects or adverse reactions, principles of drug administration the five rights, drug approval process, drug names, pharmacokinetic interaction, pharmacodynamic interactions, anticonvulsants, antipsychotics, antidepressant agent, antibacterial. This applies to both effects of the medicinal product on other drugs as well. Understand how coenzymea is used to transfer acyl groups. Taking multiple medications increases the likelihood of having at least one side effect. Many adults experience longterm use of medications that affect the central nervous system i. Define the terms metabolism, metabolic pathway, catabolism, and anabolism. Sites of biotransformationcontd liver the primary site for metabolism of almost all drugs because it is. Reaction that is particular to an individual or defined group of people. Isosreric replacement involving cylic vs noncylic analog.
Results in abnormal glucose metabolism and hyperglycemia. The term drugdrug interactions refers to the influence of one drug upon another, e. The notes, and the corresponding slides, are also freely available in pdf and powerpoint formats. Scribd is the worlds largest social reading and publishing site. The higher the lactate, the higher the risk for mortality. Winner of the standing ovation award for best powerpoint templates from presentations magazine.
Introduction cytochrome p450 nomenclature components of cyp450 mechanism catalytic cycle family of cytochrome p450 in various species genetic polymorphism spectrum of consequences of drug metabolism phases of drug metabolism conclusion references the cytochrome p450 enzymes cyps are a diverse super family of enzymes which. Neonatal hepatic metabolism overall rate of biotransformation of drugs much slower rapid physiologic changes occur in first week of life that change capacity of hepatic drug metabolism and oral bioavailability changes in hepatic blood flow, increased portal venous flow, closure of ductus venosus phase i. Metabolismwill it be metabolized properly, are there drugdrug interactions. In the first chapter, the principles underlying drug absorption, distribution, metabolism and elimination are described, with drug metabolism highlighted within the context of these fundamental processes. A drug may inhibit one isoenzyme while being itself a substrate of another isoenzyme e. Potential benefits of transdermal drug delivery advantages easy to use. The oh group is replaced by other group having ability to undergo hbonding. Phases i and ii of the metabolism of a lipophilic drug. Powerpoint is the worlds most popular presentation software which can let you create professional cholesterol metabolism powerpoint presentation easily and in no time. Introduction drug metabolism biotransformation or detoxication is the biochemical changes of the drugs and other foreign substances in the body. Ppt drug metabolism powerpoint presentation free to. In general, the clinician should consider one of 6 treatment options combined with metformin i. If you are working in powerpoint for windows and have finished your poster, save as pdf and the bars will not be included. Drug user id physicochemical properties of environment x variables.
Pharmacokinetic and pharmacodynamic considerations in. Drug metabolism pptpowerpoint presentation, medical notes. The adobe flash plugin is needed to view this content. On the mac adjust the pagesetup to match the pagesetup in powerpoint before you create a pdf. Jan 22, 2014 contents of the powerpoint on cytochrome p450 metabolism include. Contents of the powerpoint on bioavailability and firstpass metabolism include. Free download cholesterol metabolism powerpoint presentation. This document is highly rated by students and has been viewed 496 times. Developmental pharmacokinetics in pediatric populations. Guideline on the investigation of drug interactions cpmpewp56095rev. In some cases, the firstpass effect results in metabolic activation of an inert prodrug.
Find materials for this course in the pages linked along the left. Con federation of addiction research centers 150 faculty major grants from niaaa, nida, and nimh uw centers. Drug metabolism and pharmacokinetic dmpk properties of. To identify the site of biotransformation of drugs. Drugs, brains, and behavior the science of addiction. Drug metabolism pptpowerpoint presentation, medical. Phase i metabolism also often results in the introduction or unmasking of a. Absorptionconsider fooddrug interactions distributiondoes it get where it needs to go in the right concentration.
Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through. Drug metabolism drug metabolism medical treatments free. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. Exceptional customer services abilities developed in retail environment. Metabolism termination of drug action importance of drug metabolism. Drug metabolism free download as powerpoint presentation. Interaction of 2 or more drugs that result in a disadvantage to a patient. This helps you give your presentation on cholesterol metabolism in a conference, a school lecture, a business proposal, in a webinar and business and professional representations the uploader spent hisher valuable time to. Rates of alcohol, tobacco and other drug use begin early and increase through the mid 20s early use increases the risk of addiction consequences of alcohol, tobacco and drug use are great. Lipids are a group of compounds which are differentiated by their feature of solubility in nonpolar solvents and insolubility in water.
Stopping rules for administering the drug, stopping enrollment, and stopping dose escalation. Its a presentation done by me in the given topic at the pharmacology seminar organised at r. Drug metabolism by intestinal epithelium cyp3a4 drug efflux from intestinal epithelial cells pglycoprotein inhibitors of cyp3a4 and drug transporters. Gastric emptying times vary among patients and contribute significantly to intersubject variability in drug absorption. Each drug has its advantages and disadvantages, and what might be best for one patient may not be so for the next. Duration of clinical observation should be adequate with respect to. This is leading to the formation of different metabolites with different effects. This powerpoint presentation comes from the virtual cell biology classroom of science prof online, and, as such, is licensed under creative commons attributionsharealike 3. Appropriate monitoring scheme to monitor for clinical signs or symptoms of adverse events likely to be associated with the drug. Drug metabolism drug metabolism medical treatments.
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